Catálogo general Salud sexual
![Centro de Documentación y Recursos Pedagógicos. Salud sexual Centro de Documentación y Recursos Pedagógicos. Salud sexual](/img/cdrp-sexualidad-es.png)
Epidemiology, molecular characterisation and antimicrobial susceptibility of Neisseria gonorrhoeae isolates in Madrid, Spain, in 2016
Resumen
With the aim to elucidate gonococcal antimicrobial resistance (AMR)–risk factors, we undertook a retrospective analysis of the molecular epidemiology and AMR of 104 Neisseria gonorrhoeae isolates from clinical samples (urethra, rectum, pharynx and cervix) of 94 individuals attending a sexually transmitted infection clinic in Madrid (Spain) from July to October 2016, and explored potential links with socio-demographic, behavioural and clinical factors of patients. Antimicrobial susceptibility was determined by E-tests, and isolates were characterised by N. gonorrhoeae multi-antigen sequence typing. Penicillin resistance was recorded for 15.4% of isolates, and most were susceptible to tetracycline, cefixime and azithromycin; a high incidence of ciprofloxacin resistance (~40%) was found. Isolates were grouped into 51 different sequence types (STs) and 10 genogroups (G), with G2400, ST5441, ST2318, ST12547 and G2992 being the most prevalent. A significant association (P = 0.015) was evident between HIV-positive MSM individuals and having a ciprofloxacin-resistant strain. Likewise, a strong association (P = 0.047) was found between patient age of MSM and carriage of isolates expressing decreased susceptibility to azithromycin. A decrease in the incidence of AMR gonococcal strains and a change in the strain populations previously reported from other parts of Spain were observed. Of note, the prevalent multi-drug resistant genogroup G1407 was represented by only three strains in our study, while the pan-susceptible clones such as ST5441, and ST2318, associated with extragenital body sites were the most prevalent.
Autoría:
GUERRERO TORRES, M. D.; MENÉNDEZ PRIETO, Blanca; GUERRAS, Sara; TELLO, Estela; BALLESTEROS MARTÍN, Juan; CLAVO ESCRIBANO, Petunia; PUERTA LOPEZ, Teresa; VERA GARCIA, Mar; AYERDI AGUIRREBENGOA, Oskar; CARRIÓ, J. C.; MOZO MAMOLAR, Inmaculada; ROMERO GUERRERO, Jorge del; VÁZQUEZ, J. A.; ABAD, R.
Ficha bibliográfica
- Año de publicación:
- 2019
- Publicación:
- Cambridge : Cambridge University Press
- En :
- Número:
- No. 147: e274 (September 24, 2019), 11 p.
- Formato:
- Artículo
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